The Hoka One One Vanquish 3 makes the list of most comfortable Hoka One One shoes thanks to a ethylene vinyl acetate midsole and carbon rubber outsole. The shoe hugs your foot to prevent sliding, but the wide toe-box ensures your toes don't cramp up while you run. Suffer from frequently sweaty feet? The OrthoLite insole works double-duty, fighting off moisture and bacteria while also adding a layer of comfort to these shoes.